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E-cigarette use has become popular only in recent years, and it may take many more years before long-latency diseases such as emphysema and lung cancer become evident in e-cigarette users

The possible mechanisms might be the biologic and molecular pathways include enhanced insulin sensitivity, increased high-density lipoprotein (HDL) cholesterol, and improved endothelial function by decreased tissue injury via limited ischemia/reperfusion ratio induced by ethanol 35,37