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It's a small effect, sure, but detectable

A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing

Wang Y., Wang W., Su L., Ji F., Zhang M., Xie Y., Zhang T., Jiao J., Dev

TB-500 acts as an actin-binding protein that inhibits the polymerization of globular actin (G-actin) into filamentous actin (F-actin) and alters the cellular cytoskeleton [33, 34]

The activation of two transcription factors, aryl hydrocarbon receptor (AhR, which is sensitive to ROS) and hypoxia-inducible factor (HIF)-1, which is responsive to the TCA metabolites succinate, were associated with an increase in IL-22 production