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Naltrexone is registered as a prescription medication in Australia (Australian Register of Therapeutic Goods ID 128710) and is purchased from Generic Health Pty Ltd

Oral fluid tests: Also known as saliva tests, these are becoming more popular for their ease of administration and short detection window

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While CC overall inflicted more significant damage than both alternative tobacco products, the proinflammatory effects of chronic HTP inhalation were often comparable to that of CC

Participant characteristics, methodology and findings are available in Appendix 8 (available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)