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A mass-spectrometry-based framework to define the extent of disorder in proteins

TFAM binds non-specifically to all sequences of mtDNA, wrapping around the mtDNA structure to form stable protein patches

Using TUBE2 (tandem ubiquitin-binding entity 2), which serves as a pan-ubiquitin chain binder when four repeats of the UBA1 domains from HR23A are tandemly fused 29 , we found that OTUD5 pan-ubiquitylation was enhanced by the expression of wild-type, but not catalytically inactive (C1959A), TRIP12 (Fig