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In addition, to facilitate regulatory acceptance, applicants should clearly describe their NAM, including the context in which the NAM will be used (e.g., for screening/prioritization or quantitative risk assessment), the relevance of the model system to human biology and mechanisms of toxicity, and how the NAM informs the toxicological issue/gap

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Second-hand (passive) smoking occurs when people near a smoker breathe in the smoke

Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating 7AChR, ERK, HIF-1 and VEGF/PEDF signalling

The Watts Uprising occurs on August 11-16th