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Add in chain-smoking cultural icons like Serge Gainsbourg, who famously described his life as an equilateral triangle of Gitanes, alcoholism and girls, and you have a habit wrapped in art, romance and rebellion

So while the original indica plant, indigenous to the Middle East, might have differed genetically and chemically-speaking to its sativa cousin from central Asia, things are now too mixed up for there to be a clear distinction, says Myles

Ussher, M., Kahn, J., & West, R

At one year : Excess risk of coronary heart disease is half that of an active smokers

Nicotine is a highly addictive substance that can harm brain development, which continues until about age 25