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Methods Mean concentrations and the area under the curve of PM 10 , PM 2.5 and PM 1 generated by Natural American Spirit cigarettes without additives and the 3R4F standard research cigarette (University of Kentucky, USA) were measured, analyzed and compared with each other

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Rationale: Lowering the maximum concentration of nicotine allowed in vaping products is expected to contribute to reducing the appeal of these products to youth, which would help address the rapid rise in youth vaping