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Among cocaine users aged 18 to 34, 87.9% had smoked cigarettes before using cocaine, while only 3.5% used cocaine before smoking, demonstrating a strong unidirectional sequential pattern consistent with neurobiological priming rather than coincidental co-use

No effect on 3HC-Gluc formation was observed for either cannabinoid using 3HC as the substrate in microsomes from cells overexpressing UGTs 2B17, 1A9, or 2B7 for 7-OH-CBD

Fourthly, sexual behavior, socioeconomic status as well as poverty, OCs use, Pap result, as well as tobacco consumption frequency as confounding factors were not controlled for due to limited information obtained in the medical records

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