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There is some evidence that the activation of nicotinic acetylcholine receptors induces the release of endogenous opioid peptides, including the enkephalins and -endorphin 53 , and perhaps the combination of chronic morphine together with endogenous opioid agonist potentiates the level of opioid and is responsible for the suppression of cytokine expression we observed here

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Cigarettes have been the dominant form of nicotine delivery for over a century but the evidence against them has never been stronger