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After the biliary colic, if the gallbladder wall is not swollen, the physical examination may be normal or demonstrate the persistence of mild abdominal tenderness with a negative Murphys sign, because of the visceral origin [103]

Previous studies find that knockout of OAT1 or OAT3 slightly reduces uricosuria, indicating that their essential function is urate excretion ( OAT2 ( SLC22A7 ) Members of the solute carrier 22A ( SLC22A ) family known as OATs, including OAT2, are expressed in various organs (Mathialagan et al., 2018)