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The expression of constitutively active, standard immunotherapy treatment (trastuzumab and pertuzumab) resistant, truncated p95-ErbB2 in breast cancer cells activates macropinocytosis leading to increased uptake of extracellular cholesterol

Hu, Y., Dong, X

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Generally speaking, were looking at a hyperactive sympathetic (fight or flight) response and an underactive parasympathetic (rest and digest) response