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The team agrees that Setria offers formulators an advantage by allowing lower citrulline doses while maintaining benefits, potentially reducing digestive discomfort some users experience with high-dose citrulline products

DDR pathway activation phosphorylates and activates p53, which subsequently induces the expression of p21 23

Non-enzymatic antioxidants, such as glutathione (GSH), play a critical role in detoxifying ROS

Since the study was not powered for age group and sex stratification, data interpretation requires caution

The severe-risk group, received an intravenous bolus (20 mg/kg over 1 h) and infusion (105 mg/kg over 4 h) doses prior to oral NAC