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To determine whether glutathione imbalances were capable of sensitizing hepatocytes to TNF-induced cell death, hepatocytes were pretreated with H 2 O 2 (0.1 and 0.2 mM) for 2 h, followed by TNF addition (40 ng/mL)

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NAD+ helps produce cellular energy, while glutathione protects cells from oxidative stress and supports detoxification

However, it is not clear whether the two forms are physiologically similar, especially when melanogenesis is concerned

Infect Immun 62(7):27152721 Callegan MC et al (1999) Pathogenesis of gram-positive bacterial endophthalmitis