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There are few US federal regulations on e-cigarette marketing, although there is wide variation globally on how e-cigarette marketing is addressed 29

Beyond that, little is known about its potential health benefits or how it works

Information about lung cancer came from death certificates and other mortality data recorded during ensuing years Over 1,700 patients with lung cancer, all under age 75, were eligible for the case-control study

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We expect the strength of participant responses to outcomes to be strongest for the intervention groups (compared to control)