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The proteasomal degradation of MCL1, which is targeted by Parkin, may be one of the factors that induces apoptosis following mitochondrial damage, and this effect can be enhanced by BCL2-associated athanogene 5 (BAG5) and PINK1 [31,32,33]

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Perhaps even more than a daughter mourning the passing of her mother, I mourn her as a writer who has just lost her most enthralling subject. Arundhati Roy strikingly muses, cigarette in hand, on the cover of her latest memoir, Mother Mary Comes to Me. Her contemplative gaze masks emotional turmoil, audacious pluck and good ole mischief

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Similarly, smokeless tobacco consumption altered the oral microbiome, increasing inflammation-associated species and resembling the microbiome of OSCC patients