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This desensitization increases the likelihood of continued tobacco use to maintain pleasurable feelings

Negative Mood Effects: While some individuals often use tobacco to alleviate stress or improve mood temporarily, long-term tobacco use leads to mood disturbances and irritability, particularly during periods of nicotine withdrawal

"Citizens and the cigarette: The civic dimensions of America's earliest, youth-targeted, mass-mediated anti-cigarette campaign." Journal of consumer culture 13.1 (2013): 324

These medications work by targeting neurotransmitter systems in the brain involved in nicotine dependence, helping to reduce cravings and withdrawal symptoms

Nicotine dependency overrides rational decision-making, prioritizing cravings over consequences