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84 GIP receptor antagonism is thought to promote weight loss due to potential desensitization of GIP receptors by GIP agonsist exposure

Summary: In adults with overweight plus a complication or obesity without diabetes, once-weekly cagrilintide-semaglutide (CagriSema) produced substantially greater weight loss than placebo at 68 weeks

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As research continues to evolve, medical professionals must balance patient interest in cutting-edge interventions with the need for evidence-based practice

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation