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Sample size guidelines for logistic regression from observational studies with large population: emphasis on the accuracy between statistics and parameters based on real life clinical data

Evidence is primarily drawn from tobacco industry data and lacks research on long-term HnB use effects on health [footnote 30]

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Successful country models, such as integrating brief tobacco interventions into national TB programs, demonstrate that these challenges can be overcome with political commitment and tailored strategies (WHO Report on the Global Tobacco Epidemic, 2019