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For drugs that are highly susceptible to first-pass metabolism, such as nitroglycerin, lidocaine, and propranolol, only a small fraction of the oral dose may reach the systemic circulation unchanged

An enlarged liver is a rare side effect of long-term steroid use in children [140]

10.3892/ol.2012.931 Summary Keywords Alzheimers disease, glutathione, multiple sclerosis, Parkinsons disease, redox imbalance Citation Knudsen E, Tadje J, Coggins C and Venketaraman V (2026) Glutathione and neurodegenerative diseases: immunopharmacological implications