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A mitochondrial enzyme CARS2 generates cysteine persulfide from cysteine, which is regarded as one of the major processes for production of persulfides, i.e., molecular species containing more than one sulfur atoms in thiol moiety

In addition to these direct anticancer mechanisms, lignans such as schisandrin B and gomisin A have been shown to reverse MDR by inhibiting P-gp, a drug efflux transporter associated with reduced chemotherapy efficacy [90, 91]

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