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Insulin binding causes autophosphorylation of its receptor, resulting in activation and subsequent tyrosine phosphorylation of insulin receptor substrates and binding of the p85 regulatory subunit of phosphatidyl inositol kinase-3 (PI3K)

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This same enzyme was subsequently identified by two other laboratories from database searches of proteins containing the conserved G X S X G pentapeptide motif and alpha/beta-hydrolase fold, and was named adipose triglyceride lipase (ATGL) (145) or iPLA2 (53, 145)

[DOI] [PubMed] [Google Scholar] 87.Davis TR, Johnston DR, Bell FC, Cremer BJ