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Given that studies have failed to find an association between CYP2D6 polymorphism and incidence of depression (178), the most likely conclusion is the latter, in which individuals have an increased need to try different therapeutics in search of a positive therapeutic response (176, 177)

the film is almost a masterpiece of loathing, and when Lewis, as Kelp, metamorphoses into the entirely repellent Buddy Love, the effect is mesmerizing