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They used folic acid cation (FA) and triphenylphosphonium (TPP) to create a dual-targeting pro-apoptotic peptide [69]

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Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)

However, if the interactions between the cerebellum and the basal ganglia thalamocortical circuits are of any significance in movement disorders, it may be most effective to concentrate on the goal of stimulating cerebellar efferents that either directly or indirectly influence basal ganglia function