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Other factors include, but are not limited to: 1 Age nicotine clearance decreases with age Sex studies have found women metabolize nicotine and cotinine faster than men Estrogen hormones there is a strong relationship between high estrogen levels, observed in premenopausal women, and increased metabolism of nicotine Smoking tobacco itself can also impact how long nicotine stays in your system

VITAMIN B-6 Many of the B vitamins are involved in energy production, but I include B6 specifically because it has been shown to work as a cofactor with alpha ketoglutaric acid in enhancing exercise ability.23 This may be related to its role in the synthesis of hemoglobin and other oxygen transfer proteins.24 Importantly, B-6 (pyridoxine) is often poorly supplied by the American diet.2526, 27 A recent nine-year survey of American women revealed that regardless of income level, mean intakes by women were below the RDA for six nutrients, including B-6, calcium, and magnesium.28 Once converted by the body to pyridoxine 5 phosphate (PLP), vitamin B-6 becomes an active coenzyme in literally hundreds of metabolic processes