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Nerve-related symptoms such as tingling or numbness may take several weeks or months to fully improve

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The dosing regimen may depend on the specific patient population, with low-dose, long-term supplementation possibly being sufficient in healthy individuals, whilst patients with end-stage renal disease probably need higher dosages and ideally in combination with folate

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High NNMT activity has also been linked to: Poor mitochondrial function Increased oxidative stress Accelerated fat storage Inhibiting this enzyme helps reverse those metabolic imbalances