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Menthol being a popular flavor among the youth and adults 12 and a series of vanilla flavors as well as rainbow candy which were earlier evaluated for free radical generation 13

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Early attempts included Project XA by the Ligget Group, which focused on reducing cancer-causing elements in smoke, and the Premier Electronic Cigarette by RJR, designed to heat and aerosolize tobacco.

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To date there are no published clinical trials and there is no quality control to limit the amounts of chemicals in e-cigarettes, including known carcinogens