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Genes responsible for the antitumor response are hypermethylated in patients with COPD who smoke, suggesting reduced infiltration of immune cells against tumor [40]

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Origin and spread On April 12th, 2015, X user @rustcohle95 shared the image with the caption, "Trying to resist watching the leaked Game of Thrones episodes like," and from there the meme gained traction, primarily on on Reddit