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Glutathione is made up of three amino acids: glutamic acid, cysteine and glycine

In-vitro (Latin: in glass) refers to studies conducted outside of a living organism

This includes upregulation of antioxidant enzymes (superoxide dismutase, catalase) that protect against oxidative damage, enhancement of growth factor expression (TGF-, VEGF, PDGF) that supports tissue repair, and suppression of inflammatory gene expression that contributes to chronic skin degradation

It is also particularly important in the production of red blood cells and in maintaining a healthy nervous system

The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail