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E-cigarettes do not burn tobacco and may produce less harmful and potentially harmful constituents (HPHCs) as compared with combustible cigarettes 6,33,34,35,36,37

for example, the overexpression of maternally expressed 3 ( MEG3) was found in Primary Human Pulmonary Microvascular Endothelial Cells (HPMEC) induced by CS extract (CSE), and cell apoptosis was increased (25)

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Fischman MW, Schuster CR, Javaid J, Hatono Y, Davis J (1985)

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