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Additionally, elevations in FFAs in obesity contributes to GH suppression, as experimental lowering of FFA levels reverses obesity-associated impairment of GH secretion (96)

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Analysis of mRNA from the aortas of different groups showed that FOXO4-DRI effectively inhibited the increase of pro-inflammatory factors such as Il-1 , Il-6 , Cxcl15 , and Tnf- (Figure 2B)