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With regular use, the body can become accustomed to the presence of phentermine to function normally, leading to dependency, which means if the medication is stopped abruptly, the person can experience withdrawal symptoms as the body readjusts to functioning without it

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Sample size calculation The required sample size was estimated to be 363 (min 272) based on the prevalence of IBS in the general population being estimated to be 13% with an estimated error of 4%, Type 1 error (alpha) 5% (two-tailed), power 95%, and allowing for a 25% dropout rate