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10.1371/journal.pone.0210213 PLoS One

Because they're not making them in the same labs where they're making fucking Tylenol

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Exposure to cigarette smoke (Kim et al., 2014), its major constituent nicotine (Petsophonsakul et al., 2021), and electronic cigarettes ( in vitro cellular studies have shown that constituents of cigarette smoke lead to depletion of the cofactor tetrahydrobiopterin in vascular endothelial cells, which is essential for endothelial NO synthase function, resulting in uncoupling and dysfunction of endothelial NO synthase and endothelial dysfunction ( in vivo studies in smokers and in vitro studies in bovine aortic endothelial cells (Peluffo et al., 2009)

In addition to habitat conservation, these tracts will eventually be accessible to the public for outdoor recreation including hunting, wildlife watching, and birding