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Taylor et al

People who are already prone to depression have a 25% chance of becoming depressed when they quit smoking, and this increased risk persists for at least 6 months

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Certain structures of the central nervous system will transform to accommodate the nicotine as a primary source of releasing dopamine, yet at the same time, the effects of nicotine will lessen, which creates the need to consume higher doses to get the same dopaminergic effects

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