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Additionally, presynaptic dopamine released both subcortically and within the frontal regions of the brain are influenced by inhibitory GABA interneurons, therefore disruption in GABA signaling via NMDAR abnormalities has also been linked to abnormalities in dopamine signaling (73, 90, 91)

This bulge can burst and cause a subarachnoid hemorrhage, which can lead to a stroke

Cons Unpredictable Outcome

However, this analysis measured symptoms during FEP rather than the CHR period and assessed substance use retrospectively 34

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