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For miR-140-5p, its downregulation in PH patients further amplifies SMURF1-mediated suppression of BMP signaling, exacerbating pulmonary vascular remodeling, which underscores the coordinated role of these miRNAs in fine-tuning SMURF1 activity and disease progression (Baptista et al

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They serve essentially the same purpose to ensure you get the same pleasant experience without banking on the harmful effects of smoking