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Thirdly, although our analysis identified population-level associations, observational design inherently limits causal inference, and linear trend assumptions (such as EAPC) may oversimplify complex temporal dynamics affected by sudden policy shifts

Tobacco has an annual death toll of 6 million people, and that could exceed 8 million by 2030 unless something urgent is done to stop people smoking, according to the WHO

A transient heart rate pattern would suggest that the cardiovascular system adapts chronically to nicotine and requires a period of adjustment to achieve a new homeostasis after cessation

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Nelson is also contributing to the marijuana movement with his own weed company, Willie's Reserve