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It is a complex network of interlocking genetic feedback loops involving clock genes (Clock, Bmal1), period genes (Per1, Per2, Per3), and cryptochrome genes (Cry1, Cry2)

Pancreatic -cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota

But in other cases, imprinting can be positive, by promoting the development of cross-reactive antibodies that neutralize strains in both the initial and subsequent vaccines

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