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doi: 10.1186/S13148-025-01967-0 148

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Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea

and nGPX4 has a canonical nuclear localization signal, but more importantly lysine/arginine rich domains (similar to that in protamines) which facilitates nGPX4 binding to sperm DNA enabling oxidation of cysteines in protamines [47]

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