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In vivo, treated mice showed significantly reduced body weights, white adipose masses, and adipocyte sizes findings replicated across multiple independent studies from the same research group

To prevent the downstream effect of zonulin binding to its receptors after intestinal gliadin exposure, it is proposed that LA antagonizes the zonulin pathway by competitively inhibiting zonulin binding to target receptors, but further mechanistic studies are needed in order to support this proposal (Fig

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92 (2): 020104(R)