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This functional dichotomy includes the expression of specific markers, a particular cytokine pattern, and different types of energy metabolism ( Although the interior of a macrophage constitutes a hostile environment for any microbe or parasite, Leishmania adeptly manipulates host cell signaling, metabolism, and immune functions steering the macrophage toward an anti-inflammatory phenotype similar to M2 ( Leishmania unveils a dynamic relationship critical for determining the course of infection

Composed of three amino acidsglutamine, glycine, and cysteineit plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting overall cellular health

The primary outcomes were disability or death at 90 days (modified Rankin Scale, mRS3)

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Mechanisms and modulation of oxidative/nitrative stress in type 4 cardio-renal syndrome and renal sarcopenia