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In contrast, under high-iron conditions, IRPs undergo conformational inactivation and dissociate from IREs, allowing increased synthesis of ferritin and FPN1 and reduced iron uptake (Sanchez et al., 2007

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The ability of NAC to protect against the cardiovascular complications associated with diabetes was addressed in a recent systematic review that identified 49 papers reporting on in vitro and in vivo studies investigating the cardiac effects of NAC, mostly in animal models of diabetes [175]