Finally, a number of factors have previously been implicated in the emergence of transient symptoms of CAPS, notably psychosis-liability [15, 22, 48, 49], cannabis potency [41] and young age [14]
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In our study, we also observed a reverse positive association between depression and smoking initiation, which supported that patients with depressive symptoms were more likely to start cigarette smoking possibly due to a depression-releasing effect derived from smoking
Although the mechanisms are not clearly clarified about the increased risk of psychiatric diseases among smokers, pathways listed above may play a role