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The researchers state that: "to standardise the experimental treatment, smoked filters were obtained from a single 400-pack of regular filter cigarettes [Marlboro] consumed by an artificial smoking device." Or to put it another way, no humans were harmed in the carrying out of this experiment

Subjects received an initial dose of 80 mg HUMIRA followed by 40 mg every other week (starting one week after the initial dose) or placebo for 26 weeks followed by open-label HUMIRA treatment for an additional 26 weeks

However, as the crude tobacco leaf may vary a lot in different regions, it is possible that this transformation cannot reflect the exact dose of tobacco exposure