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[DOI] [PMC free article] [PubMed] [Google Scholar] Cotruvo J

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Additional reasons to seek medical advice: Symptoms suggesting pregnancy (nausea beyond typical tirzepatide side effects, breast tenderness, fatigue) Signs of infection (fever, unusual vaginal discharge, pelvic pain) Significant mood changes or depression related to menstrual irregularities Concerns about fertility or family planning while taking tirzepatide Proactive communication with your healthcare team ensures that menstrual changes are appropriately evaluated and managed, optimizing both the metabolic benefits of tirzepatide treatment and your overall reproductive health