how does tobacco affect the circulatory system smoking and vascular biology and function: evidence from human studies | Pflügers Archiv - European Journal of Physiology The Many Dangers of Tobacco

constantly running after something that wont sustain the state you desire is a waste of energy

This is all data which can be extracted, calculated, and is publicly available

Incapsula incident ID: 328000730126553923-485899266649756241

Nicotine, most likely via 7 and 42 nAChRs, may cause alterations in molecular and cellular processes, hence modulating disease in synaptic plasticity [67] Rodent model observations reveal sustained after being exposed to nicotine during embryonic development, there are increases in nicotine binding, and it seems that 42 * the more nAChRs susceptible 7 nAChRs increase regulation [67, 68]

Use of electronic cigarettes in pregnancy: A guide for midwives and other healthcare professionals