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Pregnant rats were administered midazolam using intravenous doses of 0.2, 1, and 4 mg/kg/day (0.09, 0.46, and 1.85 times the human induction dose of 0.35 mg/kg based on body surface area comparisons) during late gestation and through lactation (Gestation Day 15 through Lactation Day 21)

The results of these arsenic studies were recently confirmed in a small U.S

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However, this depends on the counterfactual of what the person would have done otherwise: if they would have remained nicotine-nave, this represents a net harm that must be factored in to the total population health impact

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