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Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

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This highlighted the synergistic effect of nanozyme-mediated ROS suppression and TI-based immunomodulation, effectively reducing cellular ROS levels

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These are circumferential tight junctions, which occlude the intercellular space between adjacent endothelial cells and a lack of pinocytotic vesicles in the cytoplasm (Brightman and Reese, 1969)