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Cigarettes face the highest tax burden among tobacco products in most jurisdictions

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Smoke-induced lung inflammation is triggered by particulate matter and in part by aldehyde exposure, which leads to increased levels of, for example, interleukin 8 (IL-8) and monocyte chemoattractant protein 1 (MCP-1) in both mouse and human lungs [19, 61, 62]

PubMed Central reported that Reynolds advertising methods were likely targeting young users through social media marketing and using models and influencers to promote the product

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