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The average annual rate of decline is approximately 0.01

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In a significant move, the FDA authorized the marketing of 20 Zyn products in early 2025, deeming them appropriate for the protection of public health based on lower toxicant levels compared to cigarettes and evidence supporting complete switching among some adult smokers, while imposing strict marketing restrictions to limit youth appeal (19)

Linear regression analysis with the enter method was employed to examine the effect of gender and the haemodynamic variables on the level of AIx in supine and upright positions (Table 2), while stepwise linear regression analysis was employed to examine the associations of demographic, laboratory, and haemodynamic variables with AIx (Supplementary Table)