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In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c cystine-glutamate exchanger

Plantz BA, Sinha J, Villarete L, Nickerson KW, Schlegel VL (2006) Pichia pastoris fermentation optimization: energy state and testing a growth-associated model

Careful optimization of IN dosing regimens will be essential for maintaining efficacy, minimizing side effects, and increasing patient compliance

However, GSH levels were not completely abolished, which may be due to the presence of GCLC-expressing cells in the tumour microenvironment (Extended Data Fig

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